Implications of gut and oral microbiota in neuroinflammatory responses in Alzheimer's disease.

A diverse and stable microbiota promotes a healthy state, nevertheless, an imbalance in gut or oral bacterial composition, called dysbiosis, can cause gastrointestinal disorders, systemic inflammatory states and oxidative stress, among others. Recently, gut and oral dysbiosis has been linked to Alzheimer's disease (AD), which is considered the most common form of dementia and a public health priority due to its high prevalence and incidence. The aim of this review is to highlight the implications of gut and oral microbiota in the neuroinflammation characteristic of AD pathology and the subsequent cognitive impairment. It is a systematic review of the current literature obtained by searching the PubMed, Web of Science and Scopus databases. The characteristic intestinal dysbiosis in AD patients leads to increased permeability of the intestinal barrier and activates immune cells in the central nervous system due to translocation of microbiota-derived metabolites and/or bacteria into the circulation leading to increased neuroinflammation and neuronal loss, thus generating the cognitive impairment characteristic of AD. The presence in the central nervous system of Porphyromonas gingivalis can cause an increased neuroinflammation and beta-amyloid peptide accumulation.

Glucocorticoid Effect in Cancer Patients.

The use of glucocorticoids is very varied in the context of cancer patients and includes the treatment of symptoms related to cancer, but also the management of the most common side effects of antitumor treatments or adverse events related to the immune system. There is a quantity of experimental evidence demonstrating that cancer cells are immunogenic. However, the effective activation of anticancer T cell responses closely depends on an efficient antigen presentation carried out by professional antigen-presenting cells such as dendritic cells (DCs). The classic strategies to improve the medical management of inflammation are aimed at exacerbating the host's immune response. Although successful in treating a number of diseases, these drugs have limited efficacy and variable responses can lead to unpredictable results. The ideal therapy should reduce inflammation without inducing immunosuppression and remains a challenge for healthcare personnel.

Analysis of Knowledge of Smoking-Related Diseases in Spanish Nursing Students.

Smoking causes significant morbidity and mortality worldwide, mainly in developed countries. In addition, it is the cause of numerous diseases in the body, despite the fact that the prevalence of tobacco use is decreasing. Nursing students, as future professionals, should be aware of action plans for cessation and information designed for smokers. To determine the level of knowledge among nursing students about smoking-related diseases and analyze the prevalence of student who smoke at the University of Leon, Spain, a descriptive cross-sectional study was carried out in which students were given an anonymous questionnaire, which was previously validated, during the 2021-2022 academic year. In a sample of 477 (79.5%) nursing students, a smoking prevalence of 17.6% was obtained. In addition, students' knowledge about the diseases directly caused by tobacco consumption and others associated with exposure to environmental smoke was assessed, and in both cases (8.03 points of 9 for consumption and 5.24 of 6 to exposure), scores were obtained that allow us to state that students do not know for sure the types of diseases that are related to tobacco use and passive smoking. In spite of this, it is necessary to continue to reduce the prevalence of smoking through different programs implemented in schools and universities, as it is also necessary to improve teaching plans when explaining smoking-related diseases, so that students, in the future, will be able to advise patients correctly.

La importancia de estar incluido en el Emerging sources Citation Index para las revistas y autores españoles / The importance of being included in the emerging sources citation index for spanish journals and authors

La evaluación de la actividad de los investigadores, de sus publicaciones y de las revistas donde se publican dichos trabajos, es un proceso continuo y necesario para poder valorar la calidad y el impacto de los mismos. Estas revistas están indexadas en diferentes bases de datos, siendo la Web Of Science una de las más importantes, junto con Scopus, debido a la cantidad de información que tiene recogida y a los rigurosos criterios que deben cumplir las revistas para ser incluidas en ella. Una nueva herramienta de esta base de datos es el Emerging Sources Citation Index, que contiene revistas que o bien están en proceso de evaluación, o bien son revistas que presentan una calidad científica acreditada en su disciplina, pero que nunca llegarán a integrarse en la Web of Science ya que su área de conocimiento es limitada y previsiblemente nunca llegaran a tener un factor de impacto suficientemente alto. El estar incluido en este recurso, como lo está ROL Revista de Enfermería, tiene un gran valor para las revistas y para los autores que publican sus trabajos en ellas ya que supone un mérito valorado en la mayoría de los procesos de evaluación de los investigadores, como por ejemplo en la Agencia Nacional de Evaluación de la Calidad y Acreditación (ANECA). (AU)

The evaluation of the activity of researchers, their publications and the journals where these works are published, is a continuous and necessary process to assess their quality and impact. These journals are indexed in different databases, being Web Of Science one of the most important, together with Scopus, due to the amount of information it has collected and the rigorous criteria that journals must meet to be included in it. A new tool of this database is the Emerging Sources Citation Index, which contains journals that are either in the process of evaluation, or are journals that have a proven scientific quality in their discipline, but that will never be included in the Web of Science because their area of knowledge is limited and they will probably never have a sufficiently high impact factor. Being included in this resource, as ROL Revista de Enfermería is, has a great value for the journals and for the authors who publish their work in them, since it is a merit valued in most of the evaluation processes of researchers, such as the National Agency for Quality Assessment and Accreditation (ANECA). (AU)

Implicaciones para la enfermería española del informe de referencia sobre la década del envejecimiento saludable 2021-2030 / Implications for spanish nursing of the reference report for a decade of healthy ageing 2021-2030

La Década del Envejecimiento Saludable reabre oportunidades para invertir en entornos adaptados a las personas mayores y en sistemas integrados de atención sanitaria y social. El objetivo de este trabajo es analizar esas ventanas de oportunidad para Enfermería. El envejecimiento saludable implica que las personas mayores contribuyen a la sociedad durante más tiempo, con oportunidades para gozar de buena salud, y para mantener y desarrollar las capacidades, y que está determinado por la capacidad funcional, la capacidad intrínseca y el entorno físico y social. Para ello, son precisos sistemas sociales y de salud integrados, transformadores y centrados en las personas, en lugar de sistemas basados únicamente en la enfermedad. Enfermería puede contribuir cambiando la forma de pensar, de sentir y de actuar con respecto a la edad y el envejecimiento, ofreciendo una atención integrada y centrada en las personas, adaptando el modelo de cuidados, con el foco en la promoción de la salud y la prevención de la enfermedad, y la atención de las personas mayores potenciando sus capacidades y su autonomía, en especial desde la Atención Primaria. Luchar contra el edadismo, formar a enfermeras en competencia de práctica avanzada, mejorar la accesibilidad, formar a las personas mayores y sus familias en materia digital, investigando sobre estos factores, son oportunidades que vuelve a abrir el Informe sobre la Década del Envejecimiento Saludable para Enfermería. (AU)

The Decade of Healthy Ageing reopens opportunities to invest in age-friendly environments and integrated health and social care systems. The aim of this paper is to analyse these windows of opportunity for Nursing. Healthy ageing implies that older people contribute to society for longer, with opportunities to have good health, and to maintain and develop capabilities, and that it is determined by functional ability, intrinsic capacity and the physical and social environment. This requires integrated, transformative and people-centred health and social systems, rather than systems based on disease. Nursing can contribute by changing the way we think, feel and act about age and ageing, offering integrated and person-centred care, adapting the model of care, with a focus on health promotion and disease prevention, and care for older people by enhancing their capabilities and autonomy, especially in primary care. Fighting against ageism, training nurses in advanced practice competency, improving accessibility, training older people and their families in digital matters, researching on these factors, are opportunities that the Decade of Healthy Ageing Report reopens for Nursing. (AU)

[Analysis of Bullying and Harassment Experienced by Fourth-Year Nursing Students in their Clinical Practice.] / Análisis de la intimidación y acoso experimentado por estudiantes de Enfermería de cuarto curso durante sus prácticas clínicas.

OBJECTIVE: Nursing students, with their inexperience and the frequent challenge of encountering new environments, are a potentially vulnerable group for bullying and harassment in the work setting. The aim of this study was to analyze the bullying and/or harassment experienced by Nursing students during their clinical practice. METHODS: A descriptive cross-sectional study was carried out at the University of León and the study population was fourth-year nursing students. The measurement instrument was a 24-item questionnaire approved by the University Ethics Committee. The chi-square test, Student's t-test and Mann Whitney U test were used for statistical analysis. RESULTS: A prevalence of 26.5% (22/83) of students who suffered episodes of bullying and/or harassment was observed; younger students suffered these events from physicians, patients and family members and/or companions to a greater extent. This produced an impact on the psychological well-being of the students, who felt depressed, humiliated and incapable, which negatively affected the level of care provided to patients. CONCLUSIONS: The overall problem studied presents a lower prevalence than that obtained in other work carried out in the rest of the world; as a consequence, there is an impact on the psychological well-being of the students that affects their level of attention to the tasks they are carrying out and their way of working with others.

OBJETIVO: Los estudiantes de Enfermería, con su inexperiencia y el desafío frecuente de encontrarse con nuevos entornos, son un grupo potencialmente vulnerable para sufrir intimidación y acoso en el ámbito del trabajo. El objetivo de este trabajo fue analizar la intimidación y/o acoso padecidos por los estudiantes de Enfermería durante sus prácticas clínicas. METODOS: Se realizó un estudio descriptivo transversal en la Universidad de León. La población a estudio fueron los estudiantes del Grado en Enfermería de cuarto curso. El instrumento de medida fue un cuestionario que constó de 24 items y que se aprobó por el Comité de Ética de la Universidad. Para el análisis estadístico se utilizó la prueba de chi-cuadrado, t de Student y la U de Mann Whitney. RESULTADOS: Se observó una prevalencia del 26,5% (n=83) de estudiantes que sufrieron episodios de intimidación y/o acoso; los estudiantes de menor edad padecieron estos hechos por parte de los médicos, pacientes y familiares y/o acompañantes en mayor medida. Esto produjo un impacto en su bienestar psicológico e hizo que se sintieran deprimidos, humillados e incapaces, lo que afectó negativamente al nivel de atención prestado a los pacientes. CONCLUSIONES: El problema global estudiado presenta una prevalencia inferior a la obtenida en otros trabajos llevados a cabo en el resto del mundo. Como consecuencia, existe un impacto en el bienestar psicológico de los estudiantes que afecta a su nivel de atención en las tareas que están llevando a cabo y a su forma de trabajar con los demás.

Análisis de la intimidación y acoso experimentado por estudiantes de Enfermería de cuarto curso durante sus prácticas clínicas / Analysis of Bullying and Harassment Experienced by Fourth-Year Nursing Students in their Clinical Practice

FUNDAMENTOS:Los estudiantes de Enfermería, con su inexperiencia y el desafío frecuente de encontrarse con nuevos entornos, son un grupo potencialmente vulnerable para sufrir intimidación y acoso en el ámbito del trabajo. El objetivo de este trabajo fue analizar la intimidación y/o acoso padecidos por los estudiantes de Enfermería durante sus prácticas clínicas. MÉTODOS: Se realizó un estudio descriptivo transversal en la Universidad de León. La población a estudio fueron los estudiantes del Grado en Enfermería de cuarto curso. El instrumento de medida fue un cuestionario que constó de 24 items y que se aprobó por el Comité de Ética de la Universidad. Para el análisis estadístico se utilizó la prueba de chi-cuadrado, t de Student y la U de Mann Whitney. RESULTADOS: Se observó una prevalencia del 26,5% (n=83) de estudiantes que sufrieron episodios de intimidación y/o acoso; los estudiantes de menor edad padecieron estos hechos por parte de los médicos, pacientes y familiares y/o acompañantes en mayor medida. Esto produjo un impacto en su bienestar psicológico e hizo que se sintieran deprimidos, humillados e incapaces, lo que afectó negativamente al nivel de atención prestado a los pacientes. CONCLUSIONES: El problema global estudiado presenta una prevalencia inferior a la obtenida en otros trabajos llevados a cabo en el resto del mundo. Como consecuencia, existe un impacto en el bienestar psicológico de los estudiantes que afecta a su nivel de atención en las tareas que están llevando a cabo y a su forma de trabajar con los demás.(AU)

BACKGROUND: Nursing students, with their inexperience and the frequent challenge of encountering new environments, are a potentially vulnerable group for bullying and harassment in the work setting. The aim of this study was to analyze the bullying and/ or harassment experienced by Nursing students during their clinical practice. METHODS: A descriptive cross-sectional study was carried out at the University of León and the study population was fourth-year nursing students. The measurement instrument was a 24-item questionnaire approved by the University Ethics Committee. The chi-square test, Student’s t-test and Mann Whitney U test were used for statistical analysis. RESULTS: A prevalence of 26.5% (22/83) of students who suffered episodes of bullying and/or harassment was observed; younger students suffered these events from physicians, patients and family members and/or companions to a greater extent. This produced an impact on the psychological well-being of the students, who felt depressed, humiliated and incapable, which negatively affected the level of care provided to patients. CONCLUSIONS: The overall problem studied presents a lower prevalence than that obtained in other work carried out in the rest of the world; as a consequence, there is an impact on the psychological well-being of the students that affects their level of attention to the tasks they are carrying out and their way of working with others.(AU)

Percepción de los pacientes sobre los cuidados de enfermería en el contexto de la crisis del COVID-19 / Patient perception of nursing care in the context of the COVID-19 crisis

Antecedentes: La pandemia de COVID-19 ha alterado considerablemente los procedimientos habituales de los sistemas sanitarios en todo el mundo. El trabajo diario se ha vuelto física y emocionalmente agotador para los profesionales sanitarios, obligados a afrontar y adaptarse a nuevos retos y situaciones estresantes. Esta situación pesa sobre la práctica diaria de enfermería. Objetivo: El presente estudio tuvo como objetivo determinar la percepción del paciente sobre los cuidados de enfermería humanizados recibidos durante su estancia hospitalaria. Método: Se realizó un estudio descriptivo, cuantitativo, transversal, en el que se realizaron entrevistas telefónicas a 357 personas >18 años que ingresaron durante más de 24 horas en el Hospital de León con el fin de evaluar la percepción del paciente. Uno de los instrumentos utilizados fue la Escala de Percepción de Conductas del Cuidado de Enfermería Humanizado (PCHE), para evaluar en tres dimensiones (D): cualidades de la práctica de enfermería (D1), apertura a la comunicación enfermera-paciente (D2) y disposición al cuidado (D3). El otro instrumento utilizado fue una encuesta de satisfacción institucional para conocer la opinión sobre la calidad de la atención al cliente en el área de hospitalización. Resultados: El porcentaje de pacientes que puntuaron como “siempre” cada dimensión fue: D1 = 91,2%; D2 = 81,4%; y D3 = 87,8%. La satisfacción del paciente obtuvo una puntuación media de 4,6 sobre 5. Conclusión: A pesar del impacto negativo del COVID-19 en el sistema de salud, los pacientes percibieron la atención de enfermería humanizada recibida como muy satisfactoria. (AU)

Related Factors and Treatment of Postoperative Delirium in Old Adult Patients: An Integrative Review.

"Postoperative delirium" is defined as delirium occurring in the hospital up to one week after a procedure or before discharge (whichever occurs first) that meets the DSM-5 diagnostic criteria. Objectives: To describe the risk factors related to this pathology and identify effective non-pharmacological forms of treatment. An integrative review of the available literature was performed. The search results considered included all quantitative studies published between 2011 and 2019 in both English and Spanish. A total of 117 studies were selected. Advanced age was identified as the principal risk factor for postoperative delirium. Nursing interventions appear to be the key to preventing or reducing the seriousness of delirium after an anaesthetic episode. The aetiology of postoperative delirium remains unknown, and no treatment exists to eliminate this pathology. The role of nursing staff is fundamental in the prevention, diagnosis, and management of the pathology.

Antibiotics Therapy in the Multi-Resistant Patient.

Antibiotic resistance is not only a European or American problem: it is a global crisis. The emergence of resistance to multiple antimicrobial agents has become a major threat to public health. The main objective of the institution's antimicrobial policy is to adapt the effective treatment to each patient, with a minimum of complications, avoid adverse reactions, control the development and spread of strains of resistant microorganisms as well as reduce hospital costs whenever possible. World Health Organization published a global list of priority pathogens of antibiotic-resistant bacteria to help prioritize research and development of new and effective antibiotic treatments. We must take into account the risk factors related to multiresistance, as well as factors that favor horizontal and vertical transmission. The need to prioritize implementation of these global strategies is complex and involves a lot of effort and valuable time; this point favors the rapid development resistance.